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JCI Insight 3, 23793708

Both mutations are located in the LBD and strongly increase AR sensitivity to cortisol and cortisone, which in turn leads to the promotion of prostate cancer cell growth 167

Typically, patients require an initial loading period of 8 weeks or anywhere between 3 9 months to achieve full benefits

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Importantly, this content supports the hypothesis by Randle and others (Randle et al., 1963) which stated that alteration in the uptake and metabolism of glucose and free fatty acids may be an instrumental process in the pathogenesis of insulin resistance, the major characteristic feature of T2D