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In response, the concept of caloric restriction mimetics (CRMs) has emerged, aiming to replicate the beneficial effects of CR without necessitating stringent dietary regimens

Amer Assoc Clin Oncol 21, 1980

2 Association of hypothyroidism and the gut microbiota Recent advances in microbiome research have markedly expanded our understanding of how the gut microbiota critically influences human health, particularly through intricate interactions with endocrine disorders such as hypothyroidism

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Estrogen decline shifts fat distribution toward the abdomen