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4-Hydroxynonenal modulates blood-brain barrier permeability in vitro through changes in lipid composition and oxidative status of endothelial cells and astrocytes

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The first hit refers to early metabolic disturbances, including excessive triglyceride accumulation within hepatocytes, insulin resistance, hyperglycemia, and hyperlipidemialeading to steatosis

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However, pemvidutide differentiates itself through favorable lean mass preservation and expanding into alcohol use disorder, a novel indication for this drug class

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