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The peptide activates vascular endothelial growth factor receptor 2 (VEGFR2), triggering the VEGFR2-Akt-eNOS pathway, which promotes angiogenesis and improves blood flow to damaged tissue

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Patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use tirzepatide, as GLP-1 receptor agonists have been associated with thyroid C-cell tumors in rodent studies

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