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TRIM59 is highly expressed in NAFLD tissues, where it interacts with GPX4 and promotes its ubiquitination, thereby accelerating fatty degeneration and ferroptosis in NAFLD [198]

Common, usually mild reactions Pain at the injection site is the single most reported complaint

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The rate of gastric emptying is therefore an important aspect to consider, as it regulates the entry of nutrients into the small intestine where the direct stimulation occurs

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Furthermore, compared to dulaglutide, tirzepatide at a dose of 0.75 mg once weekly was more effective at controlling blood glucose levels in this cohort