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Pharmaceutical research

Off-label use of drugs is both common and legal

26 These responses may involve oxytocin-mediated vagal afferent signaling and contribute to the central GLP-1 systems role in promoting a negative energy balance

These medications appear to reduce hepatic steatosis primarily through indirect mechanisms: improved insulin sensitivity reduces hepatic glucose production and lipogenesis

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Cohen MS, Mesler DE, Snipes RG, Gray TK