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These drugs can cause tubular toxicity by various mechanisms such as oxidative stress, diminishing mitochondrial function, restricting tubular transport processes, and generating oxidative stress (Perazella 2005)

Among the six complexes, the MRP7-fluoxetine complex achieved the best Glide energy score, whereas the MRP1-fluoxetine complex had the least favorable score

Oxidation Oxidation is the most common degradation pathway for peptides in solution

BMJ Case Rep 2017

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In a different study, it was discovered that migraineurs had a much lower total antioxidant capacity (TAC) than controls, but that TAC would rise following therapeutic intervention (Tripathi et al., 2018)