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The levels of GSH was slightly reduced in MPP + -treated SHSY-5Y cells, which was further restored to baseline levels by Sp, together with accompanying decrease in accumulated GSSG (Fig

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A standard curve was plotted and the linear relationship equation was obtained from the absorbance of the standards

This finding indicates a pathological neurotoxic response to MSG administration and suggests the formation of abnormal protein oligomers, leading to aberrant aggregation and deposition, which is a driving force in the pathogenesis of PD 92,93 , in accordance with the findings of Weston et al., which identified aggregated -synuclein inclusions within the nucleus as predictors of impending neuronal cell death in a mouse model of PD 94

& Brown, R