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However, a recent large global, multicenter phase II study of HCC showed that ADI-PRG-20 combined with 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) was associated with an ORR of 9.3% versus 8.15% with FOLFOX4

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As phase II detoxification enzymes, arthropod GSTs confer pesticide resistance through direct metabolism or sequestration of pesticides and indirectly by providing protection against oxidative stress induced by synthetic pesticides [22]

Yeah, you can't metabolize it