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Medication alone does not resolve trauma, rebuild coping skills, or address the emotional and relational drivers of substance use

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Colsoul B, Schraenen A, Lemaire K et al (2010) Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

The treatment area in the lower back is numbed with a local anesthetic injection before the epidural is given, so the epidural injection procedure is usually painless

DOI: 10.1186/s12906-019-2509-5, Biswas, T

Proposed mechanisms of MOTS-c: Activates AMPK Improves insulin sensitivity Enhances glucose utilization Increases metabolic flexibility Improves mitochondrial efficiency Supports exercise performance Why AMPK matters: AMPK is often called the body's metabolic master switch