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Similarly, an analysis utilizing the UK Clinical Practice Research Datalink (CPRD) revealed that GLP-1 RAs were linked to an increased incidence of intestinal obstruction requiring hospitalization, compared to sodium-glucose cotransporter-2 (SGLT-2) inhibitors (1.9 vs
In this manuscript we report: 1) for the first time our findings on the (3 + 2) methodology, 2) expanded substrate scope for the (4 + 3) annulation, 3) the identification of one of these compounds, JWU-A021, as a potent GLP-1 secretagogue, and 4) experimental evidence indicating that JWU-A021 likely operates in the intestinal L-cells by elevating the intracellular [Ca 2+ ] by means of activating the Transient Receptor Potential Ankyrin 1 channel (TRPA1) 4
Sala M, Diab R, Elaissari A, Fessi H
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The stationary phase consists of a Raptor 50 mm 2.1 mm, 2.7 m, C18 column (Restek, Bellefonte, PA) for the separation of the analytes and a Raptor C18 guard column (Restek, Bellefonte, PA)