Cisplatin treatment upregulated the expression of P66Shc in vivo and in vitro and promoted its mitochondrial translocation to exacerbate ferroptotic cell death and induce cisplatin-induced AKI [173]
Side Effects and Safety Considerations Berberine is generally well-tolerated at commonly used doses, but gastrointestinal side effects are relatively common, particularly when first starting supplementation
8 May help reduce damage to the liver Just like any other cell In the body, liver cells require high levels of antioxidants especially glutathione
Utilize third-party testing and storage
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paradoxically, certain gut-derived metabolites may help limit post-stroke inflammation and support neurorepair (Hu et al., 2022)
