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"The lowest dose is almost never the dose that people wind up being on," said Korner
Specifically, be concerned if weight loss stalls completely for more than 3 weeks despite caloric deficit, if appetite suppression is noticeably weaker than during initial weeks, if you do not notice any thermogenic effect, or if your weekly weight loss rate drops below half of what clinical trials show for your dose level
e , Change in body weight
Like GLP-1, GIP stimulates insulin secretion from pancreatic cells in a glucose-dependent manner (124)
This is the most popular split dosing schedule and likely the best compromise between side effect reduction and efficacy preservation
Bloating and Constipation on GLP-1s Bloating and constipation are the two most common digestive complaints on GLP-1s, and they usually trace back to the same root cause: slower transit
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