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Participants also showed decreases in waist circumference and improvements in overall body composition, indicating a reduction in adipose tissue

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16 Nonetheless, other GLP-1 RAs such as albiglutide has also shown reductions on MACE risk up to 22% as demonstrated by the HARMONY trial

Months prior, the FDA had also taken tirzepatide, a GLP-1 and GIP dual receptor and the active ingredient in weight-loss drug Zepbound and type 2 diabetes drug Mounjaro, off a similar shortage list

This magnitude of weight loss itself can affect skin and nerve function, independent of the direct pharmacological effects

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