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We aim to investigate mechanisms of rescue action of amlodipine in the murine model of iron overload, characterize changes in human cardiac tissue due to IOC, and compare them to the changes in the animal model of IOC

Rodent doses may not translate directly to human physiology

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Dosage:1 unit daily as usual for 10 day loading then 1 unit every 2nd or 3rd day for thebalance