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Indeed, there are multiple primary or secondary bile acid chemosensors in the liver (348, 354) or scattered along the gastrointestinal tract (355), where they ensure a direct negative feedback aiding detoxification (356) and protecting from hepatotoxicity and carcinogenicity displayed by some secondary bile salt such as lithocholic acid

The main changes in cholesterol load are in the esterified form of cholesterol from lipoproteins of hypercholesterolemic rabbits

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Peer review Peer review information Nature Communications thanks Cristina Al-Khalili Szigyarto and the other, anonymous, reviewers for their contribution to the peer review of this work

July 1st, 2025: Ozempic MDL Update July JPML Report The Ozempic multidistrict litigation (MDL) has expanded to 1,997 cases as of July 2025, marking an increase from 1,882 cases reported in June