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The authors induced acute inflammation in mice by administering lipopolysaccharides (LPS) a component of bacterial cell walls and then monitored changes in permeability of the BBB

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For non-injectable routes, GHK-Cu has been listed by FDA as a Category 1 bulk drug substance under 503A compounding review

This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors

These investigations focus on laboratory-based analysis of enzyme activity markers, metabolic signaling indicators, and pathway-level interactions relevant to experimental research contexts