glp-1 and gip receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function Dual GIP/GLP-1 receptor agonists: New

Abbreviations used in this paper: GLP-1 glucagon-like peptide-1 GLP-1R GLP-1 receptor T2D type 2 diabetes mellitus GLP-1RA GLP-1R agonists GPCR G-protein coupled receptor cAMP cyclic adenosine monophosphate PKA protein kinase A FDA Food and Drug Administration LPS lipopolysaccharide ALI acute lung injury OVA ovalbumin Th2 CD4+ T-helper type 2 ILC2s group 2 innate lymphoid cells IL-33 interleukin-33 DC dendritic cells FEV 1 forced expiratory volume in one second FVC forced vital capacity Th2-high type 2 inflammation high Th2-low type 2 inflammation low BALF bronchoalveolar lavage fluid TSLP thymic stromal lymphopoietin NO nitric oxide DPP-IV dipeptidyl peptidase IV GATA-3 Glucagon-like peptide-1 receptor Agonist Treatment in Adult, obesity-replated, symptomatic asthma Footnotes Conflicts of interest: KN Cahill has served on scientific advisory boards for GlaxoSmithKline, Regeneron, Genentech, Sanofi, Novartis, and AztraZeneca and served as a consultant for Ribon Therapeutics and Verantos outside the submitted work

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