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Clinical trials have included both male and female participants, with some notable observations: Metabolic differences Men typically have higher baseline metabolic rates and different fat distribution patterns, which may influence response magnitude but not optimal dosing protocols

Newer clinical trial data also include reports of dysesthesia, or unusual skin sensations, which patients should discuss with a clinician

During this time, participants may need to attend clinic visits, follow a treatment schedule, and keep a health journal

While during this time frame the percentage of new users with type 2 diabetes decreased, there was a twofold increase in the proportions of users without type 2 diabetes and a BMI of 30 kg/m 2 or greater, as well as in participants with a BMI of 27 to 30 kg/m 2 and an obesity-related comorbid condition

As of January 31, 2026, 77.8% had engaged on or after week 4

Monthly bloodwork tracks all key markers