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2013;19(1):76 to 83

Freiherr J, Hallschmid M, Frey WH et al (2013) Intranasal insulin as a treatment for Alzheimers disease: a review of basic research and clinical evidence

The activity of NO as a biological messenger classifies it as a gasotransmitter

Free Cu2+ is toxic (Fenton reactions, hydroxyl radicals), but the GHK-Cu complex is stable, diffusible and delivers copper in a targeted manner to copper-dependent metalloenzymes: lysyl oxidase (collagen/elastin crosslinking), Cu/Zn superoxide dismutase (SOD1, antioxidant defence), tyrosinase (controlled melanogenesis), dopamine-beta-hydroxylase

[DOI] [PubMed] [Google Scholar] 43.Zhao Y., Huang H., Lv N., et al

Int J Mol Sci (2021) 22(4):1786