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For instance, a study on ME/CFS demonstrated the efficacy of the tricarboxylic acid (TCA) cycle metabolite oxaloacetate in improving symptoms (Cash and Kaufman, 2023), patients showed marked improvements in fatigue scores as measured by the Chalder Fatigue Questionnaire in a randomized, double-blind, placebo-controlled trial using AXA1125

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al