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By acting as a selective 2-adrenergic agonist at the locus coeruleus and dorsal horn, DEX provides calm, physiological sedation while decreasing pain signal transmission without affecting breathing (Figure 2) (82, 229)

Ibeas, J.I., Yun, D.J., Damsz, B., Narasimhan, M.L., Uesono, Y., Ribas, J.C., et al., Plant J

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