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A study on the intestinal microbiome of young and old mice has revealed that the gut microbial-derived metabolite 3-hydroxyphenylacetic acid upregulates GPX4 expression, inhibits ferroptosis, and alleviates spermatogenic dysfunction in aging mice [108]

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14 Hence, an increasing number of scientists are beginning to focus on discovering specific agonists or inhibitors of H 2 S-generating enzymes (CBS, CSE, 3-MST) based on drug screening technologies (Table 3 and Fig