Due to the inability of ubiquitin chains to directly bind to autophagosome membranes and Autophagy-related protein 8 (ATG8) family proteins, an intermediary is required, known as autophagy adaptor proteins [39]
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Authors concluded that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and subsequently DNA becomes methylated and inaccessible resulting in transcriptional silencing thus demonstrating interplay between histone reprogramming and promoter region methylation (Okino et al., 2007)
