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They are still being studied and are not yet FDA-approved

Neither semaglutide nor tirzepatide touches the glucagon receptor

The Takeaway While both Novo and Lilly have multi-year regulatory head-starts and are now rapidly becoming part of the zeitgeist around treating obesity, Regenerons angle of addressing muscle loss could help set it apart from other GLP-1 hopefuls and even incumbents by leading to improved long-term outcomes.

Chae BJ, Lee KS, Hwang I, Yu JW

A systematic review of event rates in clinical trials in diabetes mellitus: the importance of quantifying baseline cardiovascular disease history and proteinuria and implications for clinical trial design

The multiple pharmacological treatment options will enhance clinicians ability to identify effective personalised regimens by trying a second medication or combining medications with synergistic or complimentary actions or even escalating treatment to bariatric surgery based on patient preference and underlying comorbidities [7]