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CD19 + CD38 + Akt + B cells one - way ANOVA p = 0.0023, Sidaks post-hoc test p values corrected for multiple comparisons: B6.TC (Veh) vs B6.TC/Rab4A Q72L (Veh) p = 0.0027, B6.TC/Rab4A Q72L (Veh) vs B6.TC/Rab4A Q72L (NAC) p = 0.0018, B6.TC/Rab4A Q72L (Veh) vs B6.TC/Rab4A Q72L (Rapa) p = 0.0187, B6.TC/Rab4A Q72L (Veh) vs B6.TC/Rab4A Q72L -KO (Veh) p = 0.0031

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So, there is a need for GSH to be regenerated in RBCs even normally, but that is met by two minor sources of NADPH: Cytoplasmic Isocitrate Dehydrogenase

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