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Mulkey RM, Herron CE, Malenka RC (1993)

Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

eLife 10:137 Arcaro A, Wymann MP (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

Nauck MA, Frossard JL, Barkin JS, Anglin G, Hensley IE, Harper KD, et al

Lamballe et al., 2011