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However, a two-day shift is more likely to cause increased nausea or fatigue than a one-day shift, so it should only be done when absolutely necessary

Additional studies have demonstrated that TMAO is important for the development and progression of cardiovascular diseases (e.g., hypertension, atherosclerosis, coronary artery disease, and heart failure) It is commonly agreed that TMAO acts as an independent risk factor and a prognostic index for patients with cardiovascular disease and been found to induce aortic stiffening and increases systolic blood pressure

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[DOI] [PubMed] [Google Scholar] 26.Shorr RI, Ray WA, Daugherty JR, Griffin MR

in English) , vol

Nature 518 , 187196 (2015)