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Fatigue that progressively worsens rather than improving over time may indicate an underlying issue requiring investigation

These include: Severe abdominal pain, nausea, or vomiting (which may indicate pancreatitisstop Zepbound immediately and seek urgent care) Symptoms of gallbladder disease (right upper abdominal pain, nausea, vomiting) Signs of severe dehydration (extreme thirst, dizziness, dark urine) Unexplained fatigue, cold intolerance, hair loss, or constipation (which may suggest thyroid dysfunction) New or worsening edema Significant changes in appetite or gastrointestinal symptoms beyond typical Zepbound side effects Mood changes including depression or anxiety Patients with diabetes should also watch for signs of hypoglycemia, especially if taking insulin or sulfonylureas

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Proper technique and site rotation minimize discomfort over time

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