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Meaningful savings, but still a substantial monthly expense for patients paying cash

Dementia frequently coexists with hepatic encephalopathy but not other cirrhosis complications in US Veterans

Also, we know that these drugs do not cross the blood brain barrier

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In the LEADER trial, over 9,340 patients with type 2 diabetes and high cardiovascular disease risk underwent randomization to liraglutide or placebo and were followed for a median of 3.8 years resulting in a 13% risk reduction in a combined endpoint of death from cardiovascular cause, nonfatal myocardial infarction, or nonfatal stroke [46]

Tirzepatide has no established direct mechanism causing vitamin B12 deficiency, unlike metformin