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Tirzepatide activates both GLP-1 and GIP (glucose-dependent insulinotropic peptide) receptors, producing greater weight loss than semaglutide alone in head-to-head trials

doi: 10.1038/nrneph.2017.181 157 Rodriguez-RodriguezAEDonate-CorreaJLuis-LimaSDiaz-MartinLRodriguez-GonzalezCPerez-PerezJAet al

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Pharmacol Res 177:106118