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METHODS Animals For this study, 50 male Sprague Dawley rats, 4 to 6 weeks old [26], weighing 200 to 250 g, were kept in the standard laboratory conditions, with 12-hour cycles of light and dark, room temperature of 23 1C, and relative humidity of 45 1%, in the animal house of the National Institute of Health (NIH) Chak Shehzad Islamabad

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