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Each receptor plays a distinct role in energy balance and weight regulation

Who Is Generally Excluded FDA labels list contraindications and precautions that typically rule out or require caution with GLP-1 therapy: Personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to the drug History of pancreatitis (caution, not absolute contraindication) Active gallbladder disease (caution) Severe gastroparesis or other significant GI motility disorders Pregnancy or planning pregnancy (discontinuation typically recommended) Type 1 diabetes (not studied for this indication) Additionally, patients with severe kidney or liver disease, those on certain medications that affect insulin or GI motility, and those with eating disorders should have careful evaluation

Women-specific considerations Several GLP-1 concerns are specific to women

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Alessia Roehnelt for an in-depth discussion on insulin resistance and why it is one of the most important predictors of long-term health outcomes

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