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The onset of OA pathology in cartilage is marked by an early shift in chondrocyte phenotype from a homeostatic to a catabolic and hypertrophic state

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Glutathione is your body's strongest antioxidant

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However, dietary supplements, while recommended in some cases, cannot replace a healthful diet. The Dietary Guidelines for Americans describe a healthy diet as one that: Emphasizes a variety of fruits, vegetables, whole grains, and fat-free or low-fat milk and milk products: Milk and milk products are good sources of vitamin B12

Comprehensive GSH Antioxidant Function Review (PubMed, 2023) GSH as the Central Non-Enzymatic Antioxidant in Mammalian Cells A comprehensive review of reduced glutathione (GSH) published on PubMed confirmed that GSH is an essential non-enzymatic antioxidant in mammalian cells that acts directly to protect cells against free radicals and pro-oxidants, and as a cofactor for antioxidant and detoxification enzymes including glutathione peroxidases, glutathione S-transferases, and glyoxalases