Glutathiones reduced form (GSH): Carries an extra electron (hydrogen) Donates hydrogen (electron) to inflammation-causing free radicals to neutralize their effect Glutathione peroxidase enzyme Requires selenium Converts two hydrogen peroxides into two water molecules Glutathiones oxidized form (GSSG): State of glutathione after losing its electron Forms a disulfide bridge between two glutathione molecules Glutathione reductase enzyme Glutathione can be recycled back to its reduced form using NADPH (reducing agent, electron donor)
Overdose Symptoms of glutathione overdose may include: Severe abdominal cramping Difficulty breathing or bronchospasm Signs of organ toxicity If overdose is suspected, seek emergency medical attention or contact Poison Control immediately
That matters because the absence of vomiting doesn't mean the nervous system has fully reset
Yang, R., Dong, S., Zhang, J., Zhu, S., Miao, G., & Zhang, B
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Decreased GSH then results in lipid peroxide accumulation and induction of ferroptosis