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Mounjaro, a newer medication, contains tirzepatide, which works similarly to GLP-1 but also activates GIP receptors, resulting in enhanced weight loss

Commercially available enzyme-linked immunosorbent assays (ELISAs) were used according to the manufacturers instruction to measure insulin (Crystal Chem Zaandam, 90080), total GIP (Sigma-Aldrich, EZRMGIP-55K), triglycerides (Wako Chemicals, 290-63701 or Abcam, ab65336) or total cholesterol (Thermo Fisher Scientific, 10178058)

76,77 Proliferation of astrocytes is an indispensable part of reactive astrogliosis, and suppression of proliferation exacerbates damage and delays wound closure

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However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)

10.1038/kisup.2014.16 71 TangS