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So, the broader question is whether it is both clinically and economically better to aggressively treat certain high-risk obese patients sooner, or risk downstream cost and clinical complexity later

JACC 84 , 16321642 (2024)

Trials usually focus on percentage change at set follow-up points rather than a weekly promise

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PackerMZileMRKramerCMBaumSJLitwinSEMenonVet al

There is no established therapeutic dose, and claims about metabolic benefits lack robust clinical validation