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Glucocorticoids, the main medication used to treat PM, suppress the muscle injury caused by inflammation, but can also cause damage to the muscle themselves, leading to persistent muscle weakness

More significantly, RA patients already on DMARDs (disease-modifying antirheumatic drugs) who added a GLP-1 agonist had fewer disease flares than those on DMARDs alone

Once you can tolerate regular food and fluids without nausea, your healthcare provider can restart semaglutide or tirzepatide injections

While this research wasnt focused on microdosing specifically, it helps explain why some patients report improvements in pain and fatigue at lower doses