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To account for these variations, a full calendar year was selected as the measure's performance period, to allow time to capture seasonal variations in the reported outcomes and allow hospitals and health systems sufficient time to analyze data and implement quality improvement efforts

used gradient-boosted trees with regularization for rare variants obtained from whole exome sequencing data to predict individuals at high risk for schizophrenia

Sedating psychotropics are best administered in a single dose at night

Sleep-disrupting stimulants late in the day are not

The relief is usually immediate and noticeable

The clinical trial protocol explicitly allowed for delayed escalation based on tolerability