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Rarely, individuals may experience more severe reactions, such as anaphylaxis, which requires immediate medical attention
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Other signs may include shortness of breath, pale skin, stomach problems, such as constipation, diarrhea or gas, or nerve problems, like muscle weakness or tingling in fingers or toes. Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says
Blood, 112 (6), 22142221
Concentrations above 2 percent are rarely necessary and may increase irritation risk without proportional benefit
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