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doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date

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Moreover, dose-dependent increases in heart rate and drops in systolic blood pressure were seen, but by Day 29, they had almost completely recovered to baseline levels