Human COP1 plays a key role in the ubiquitination of a wide range of transcriptional regulators, including p53, c-Jun, and members of the ETS, and C/EBP families 20,25,26,27,28,29
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Phosphorylation of 4EBP1 prevents it from binding to eIF-4E
Most patients notice appetite reduction within the first few weeks
Attention to solution tonicity and pH to limit irritation