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GLP-1R is expressed in the pancreas, gastrointestinal tract, heart, lungs, kidneys, and brain, and the localization of these receptors determines GLP-1RAs effects [89]

Used for diabetes control since 2014, these GLP-1 receptor agonists were approved in the United States for weight loss in 2021

Researchers have found that ipamorelin can stimulate the smooth muscle of the digestive lining to help food move more quickly through the digestive system [7]

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