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Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness to minimize the risk of hypoglycemia or hyperglycemia [see Warnings and Precautions (5.2) and Use in Specific Populations (8.6, 8.7)]

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For each post-surgical visit, the participants underwent four runs of DBS ON (130 Hz continuous stimulation) blood-oxygen-level-dependent (BOLD) fMRI (25 min) followed by four runs of DBS OFF fMRI (25 min)