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The potential of GLP-1RAs to induce psychiatric adverse events is biologically plausible given the widespread expression of GLP-1 receptors in the central nervous system,167 their influence on neurocognitive function,168 and their effects on inflammation, stress response, and energy metabolism, which theoretically could improve mood.169 A meta-analysis170 of 11 RCTs investigating the relationship between GLP-1RAs and mental health reported 318 and 281 psychiatric adverse events in the GLP-1RAs and control groups, respectively, with no evidence of publication bias and no significant differences between the GLP-1RAs and placebo groups
90 Taken together, these findings indicate that autophagy is involved in the occurrence and development of UC and that the inhibition of autophagy could be a therapeutic strategy for treating UC by alleviating intestinal inflammation
Food Bioprod Process 90:413424
Heart Health and Cardiovascular Protection Several large clinical trials have shown that GLP-1 receptor agonists reduce the risk of major cardiovascular events
The patient was not diabetic nor obese and they had no traditional risk factors for regurgitation or aspiration
