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The stronger correlation between changes in waist circumference and body weight in the semaglutide group compared with placebo suggests that weight loss induced by semaglutide preferentially targets visceral adipositybut this still accounts for only a minority of the cardiovascular protection

While the FDA label does not list alcohol as a contraindication, combining alcohol with tirzepatide requires careful consideration

it is not approved by the FDA, quality and potency depend entirely on the pharmacy standards

They may suit patients who: Prefer a time-limited device rather than long-term medication Need appetite reset and portion control support Are unsuitable for GLP-1-based therapy Typical outcomes range between 1015% total body weight loss over 612 months, with stronger results when structured aftercare is provided