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Feb 22, 2026 Some people notice changes within days

Heres a general breakdown of some common GLP-1 medications: Ozempic (semaglutide): Stays in your system for about 5-6 weeks after the last dose due to its long half-life of approximately 7 days per dose

IPTW consistently indicated a positive association between DPP-4i and major CI, reinforcing our primary findings

A few mechanisms that don't reduce neatly to mesolimbic dopamine: (1) conditioned aversion, GLP-1 activation engages nausea/malaise circuits, so some of the reduction in substance use may reflect aversive conditioning rather than reward modulation per se

& Shughrue, P