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Further research is essential to thoroughly investigate HO-1s regulatory mechanisms, its interaction with other transcription factors, and its functions across varying kinds and phases of diabetes

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After 3 weeks of running wheel exercise, traumatically injured mice had significantly higher levels of COXI, COXII, COXIII, BDNF, synapsin I, and ATP in the hippocampus than the controls, suggesting that exercise increases oxidative phosphorylation and ATP production in mitochondria, leading to reduced loss of neurons and better recovery of cognitive function after TBI [107]

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Liver cells, presumably hepatocytes, take up heme-HPX and heme is released intracellularly while apo-hemopexin is recycled to the plasma