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To better isolate a true Type 1 diabetic population, they excluded individuals with Type 2 diabetes and those taking sodiumglucose cotransporter-2 (SGLT2) inhibitors

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Based on preclinical studies, a systematic review of the neuroprotective mechanisms of GLP-1RA-based therapy in ischemic stroke [67] has shown that administration of drugs of this family before, during, or after an experimental stroke in animals with and without diabetes modulates an acute inflammatory response secondary to brain ischemia, reducing inflammation, endothelial dysfunction and excitotoxicity, as well as decreasing oxidative stress and apoptosis

Koren, who has worked in clinical research for 35 years, said he is now studying a different class of incretin called an amylin agonist that takes a distinct approach to appetite control