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The release of bromelain in tumour-bearing mice by pH-sensitive NPs increased the hydrolysis of the ECM favoring the penetration of the anticancer drug (164)

These include methods for direct reactive oxygen species (ROS) detection (e.g., superoxide, hydrogen peroxide), characterization of oxidative damage to lipids (e.g., TBARS, F2-isoprostanes

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Indeed, it was recently demonstrated that the pentose phosphate pathway (PPP), a major contributor of NADPH for the maintenance of glutathione in its reduced state, is critical for NRF2-induced proliferation [58, 59]

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When multiple reports from the same population were retrieved, the most complete or recently reported data were used